Journal article
Postnatal inflammation in ApoE−/− mice is associated with immune training and atherosclerosis
EC Noye, S Bekkering, AP Limawan, MU Nguyen, LK Widiasmoko, H Lu, S Pepe, MM Cheung, TR Menheniott, MJ Wallace, TJ Moss, DP Burgner, KR Short
Clinical Science | PORTLAND PRESS LTD | Published : 2021
DOI: 10.1042/CS20210496
Abstract
Background and aims: Preterm birth is associated with increased risk of cardiovascular disease (CVD). This may reflect a legacy of inflammatory exposures such as chorioamnionitis which complicate pregnancies delivering preterm, or recurrent early-life infections, which are common in preterm infants. We previously reported that experimental chorioamnionitis followed by postnatal inflammation has additive and deleterious effects on atherosclerosis in ApoE−/− mice. Here, we aimed to investigate whether innate immune training is a contributory inflammatory mechanism in this murine model of atherosclerosis. Methods: Bone marrow-derived macrophages and peritoneal macrophages were isolated from 13-..
View full abstractGrants
Awarded by National Heart Foundation of Australia
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia : Program [grant number 606789], Centre for Research Excellence [grant number 1057514], Research Fellowships [grant numbers 1043294 (to T.J.M.), 1064629 (to D.P.B.)]; the National Heart Foundation Australia [grant number G12M6422]; the Victorian Government's Operational Infrastructure Support Program; the Rubicon grant from the Dutch Scientific Organisation (NWO) [grant number 452173113 (to S.B.)]; AustralianResearch Council (Fellowship DE180100512 to K.R.S.), the Post-graduate Biomedical Scholarship of the National Heart Foundation (Australia) [grant number PB12M6953]; and an Honorary Future Fellow of the National Heart Foundation (Australia) [grant number 100026 (to D.P.B.)]; Investigator grant [grant number GTN1175744 (to D.P.B)].